May 26, 2018

Profile hidden Markov models for biological sequence analysis

HMMER is an implementation of profile hidden Markov model methods for sensitive searches of biological sequence databases using multiple sequence alignments as queries.

Given a multiple sequence alignment as input, HMMER builds a statistical model called a “hidden Markov model” which can then be used as a query into a sequence database to find and/or align additional homologues of the sequence family.

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